Abstract | OBJECTIVE: METHODS: In the present study we have evaluated the relationship between plasma adiponectin concentrations and hypertensive retinopathy. One hundred and ten patients newly diagnosed with essential hypertension (EHT) (mean age, 46.79+/-5.0 years; body mass index (BMI), 26.47+/-2.23 kg/m(2); male/female ratio, 58/52) and 57 healthy normotensive control subjects (NT) (mean age, 46.84+/-5.4 years; BMI, 26.66+/-2.65 kg/m(2); male/female ratio, 33/24) were enrolled. RESULTS: Plasma adiponectin levels were significantly lower in EHT than in NT (P < 0.001). In addition, adiponectin concentrations were strongly correlated with systolic and diastolic blood pressures in EHT (r = -0.757, P < 0.001; r = -0.761, P < 0.001) while there was no correlation in the NT group. Plasma adiponectin in patients with grade 0 hypertensive retinopathy (n = 52) was significantly higher than that of the patients with grade 1 ( n = 30) and 2 (n = 28) hypertensive retinopathy (P < 0.001 for each). Plasma adiponectin in patients with grade 0 hypertensive retinopathy was also significantly lower than that in the NT group (P < 0.001). The estimated threshold of plasma adiponectin concentration for hypertensive retinopathy was 17 microg/ml. This critical adiponectin level served largely to separate patients with retinopathy from those without. CONCLUSION: Our results have shown that plasma adiponectin concentrations decrease progressively with higher grades of hypertensive retinopathy even after correction for other atherogenic risk factors, suggesting that a critical adiponectin level is needed for the development of retinopathy.
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Authors | Mahmut Ilker Yilmaz, Alper Sonmez, Selim Kilic, Turgay Celik, Necati Bingol, Murat Pinar, Tarkan Mumcuoglu, Metin Ozata |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 152
Issue 2
Pg. 233-40
(Feb 2005)
ISSN: 0804-4643 [Print] England |
PMID | 15745931
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adiponectin
- Intercellular Signaling Peptides and Proteins
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Topics |
- Adiponectin
- Adult
- Case-Control Studies
- Female
- Humans
- Hypertension
(blood, epidemiology)
- Intercellular Signaling Peptides and Proteins
(blood)
- Male
- Middle Aged
- Neovascularization, Pathologic
(blood, epidemiology)
- Retinal Diseases
(blood, epidemiology)
- Risk Factors
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