Transvalencin A, a thiazolidine zinc complex antibiotic produced by a clinical isolate of Nocardia transvalensis. II. Structure elucidation.

Abstract

A novel antifungal antibiotic, transvalencin A, is produced by Nocardia transvalensis IFM 10065 isolated from a patient with actinomycotic mycetoma in Japan. The antibiotic structure was elucidated using NMR, mass spectrometric investigations, and X-ray crystallographic analysis. Transvalencin A is a 1:1 complex of a zinc and an organic acid with a phenolic substituent. Transvalencin A is comprised of o-substituted p-chlorophenol, tetrasubstituted oxazoline, disubstituted thiazolyl-N-methylthiazolidine and monosubstituted N-methylthiazolidine.

• Authors: Yasutaka Hoshino, Akira Mukai, Katsukiyo Yazawa, Jun Uno, Akikazu Ando, Yuzuru Mikami, Toshio Fukai, Jun Ishikawa, Kentaro Yamaguchi
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 57 Issue 12 Pg. 803-7 (Dec 2004) ISSN: 0021-8820 [Print] England
• PMID: 15745115 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Organometallic Compounds
• Thiazoles
• transvalencin A
• Zinc

Topics

• Anti-Bacterial Agents (chemistry)
• Magnetic Resonance Spectroscopy
• Mass Spectrometry
• Models, Molecular
• Molecular Structure
• Nocardia (chemistry)
• Organometallic Compounds (chemistry)
• Thiazoles (chemistry)
• Zinc (chemistry)