Abstract | BACKGROUND: Periconceptional intake of nutrients in addition to folic acid may contribute to neural tube defect (NTD) etiologies; a likely candidate is myo- inositol. We investigated whether maternal periconceptional dietary intake of myo- inositol influenced NTD risk. METHODS: Data were derived from a case-control study of fetuses and infants with NTDs among 1989-1991 California births. Interviews were conducted with mothers of 454 NTD cases and with mothers of 462 nonmalformed controls. A standard 100-item food frequency questionnaire was used to assess nutrient intake. RESULTS: We observed small increases in risk, with increases slightly more evident for anencephaly, associated with intakes of myo- inositol less than the highest intake quartile, e.g., risk of anencephaly was 1.3 (0.7-2.4) among fetuses whose mothers consumed lowest versus highest intakes of myo- inositol. These small increases, however, were imprecise, and also did not indicate increasing risk with decreasing level of myo- inositol intake. Adjusted risk estimates did not differ considerably from their unadjusted counterparts. CONCLUSIONS: Our results do not indicate that myo- inositol intake, as measured in this study, is strongly associated with risk of human NTDs.
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Authors | Gary M Shaw, Suzan L Carmichael, Wei Yang, Donna M Schaffer |
Journal | Birth defects research. Part A, Clinical and molecular teratology
(Birth Defects Res A Clin Mol Teratol)
Vol. 73
Issue 3
Pg. 184-7
(Mar 2005)
ISSN: 1542-0752 [Print] United States |
PMID | 15744734
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Copyright | Copyright 2005 Wiley-Liss, Inc. |
Chemical References |
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Topics |
- Female
- Humans
- Inositol
(adverse effects)
- Maternal Exposure
- Neural Tube Defects
(epidemiology)
- Pregnancy
- Prenatal Exposure Delayed Effects
- Risk Factors
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