Araloside A, an antiulcer constituent from the root bark of Aralia elata.

Abstract	Araloside A, a potent inhibitor of gastric lesion and ulcer formation in rats, was isolated from the root bark of Aralia elata through a bioassay-guided separation procedure. The compound exhibited significant reduction of HCl.ethanol-induced gastric lesions and aspirin-induced gastric ulcers at oral doses of 50 and 100 mg/kg, respectively. These activities are comparable to those of cimetidine.
Authors	Eun Bang Lee, Oon Ja Kim, Sam Sik Kang, Choonsik Jeong
Journal	Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 28 Issue 3 Pg. 523-6 (Mar 2005) ISSN: 0918-6158 [Print] Japan
PMID	15744082 (Publication Type: Comparative Study, Journal Article)
Chemical References	Anti-Ulcer Agents Plant Extracts Saponins Oleanolic Acid araloside A
Topics	Animals Anti-Ulcer Agents (isolation & purification, therapeutic use) Aralia Male Oleanolic Acid (analogs & derivatives, isolation & purification, therapeutic use) Plant Bark Plant Extracts (isolation & purification, therapeutic use) Plant Roots Rats Rats, Sprague-Dawley Saponins (isolation & purification, therapeutic use) Stomach Ulcer (drug therapy, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!