Dual treatment of albendazole in hepatic hydatidosis: New therapeutic modality in 52 cases.

Abstract

BACKGROUND:

Hepatic hydatidosis still remains as a serious problem in general surgery. Recurrence and/or secondary hydatidosis rates are up to 25% in the cases treated with surgery alone. Albendazole is the most commonly used drug in the medical treatment of echinococcosis. The aim of the present study was to evaluate the effect of albendazole using the intraoperative and perioperative periods as dual therapy.

METHODS:

Fifty-two cases of hepatic hydatidosis were evaluated and treated by dual treatment of albendazole together with surgery. Perioperative albendazole treatment was given in a dose of 12-15 mg/kg per day in four divided doses. The treatment started 2-28 days before the surgery when the diagnosis was established and continued for 2-24 months (4.76 +/- 3.25) postoperatively in a cyclic monthly form. A total of 1.7 microg/mL albendazole solution was used as a protoscolicidal agent in the cystic cavity intraoperatively. In the postoperative period serology, ultrasonography and computed tomography evaluations were done. The follow-up period was 5-92 months (mean: 62.48 months).

RESULTS:

There was no recurrence in the present study. One patient died in the 6th postoperative week due to cerebral hydatidosis and multiple organ failure. Early and late morbidity rates were 7.69 and 9.61%, respectively.

CONCLUSIONS:

Dual albendazole treatment is effective in the prevention of recurrences and/or secondary hydatidosis.

• Authors: Cafer Polat, Adem Dervisoglu, Murat Hokelek, Ibrahim Yetim, Yalcin Buyukkarabacak, Yasin Ozkutuk, Kenan Erzurumlu
• Journal: Journal of gastroenterology and hepatology (J Gastroenterol Hepatol) Vol. 20 Issue 3 Pg. 421-5 (Mar 2005) ISSN: 0815-9319 [Print] Australia
• PMID: 15740487 (Publication Type: Comparative Study, Evaluation Study, Journal Article)

Chemical References

• Anticestodal Agents
• Albendazole

Topics

• Adult
• Aged
• Albendazole (administration & dosage, therapeutic use)
• Anticestodal Agents (administration & dosage, therapeutic use)
• Combined Modality Therapy
• Drug Administration Routes
• Echinococcosis, Hepatic (drug therapy, surgery)
• Female
• Follow-Up Studies
• Humans
• Intraoperative Period
• Laparoscopy (methods)
• Male
• Middle Aged
• Perioperative Care
• Postoperative Period
• Retrospective Studies
• Suction
• Treatment Outcome
• Video Recording