Photothermal sensitisation: evidence for the lack of oxygen effect on the photosensitising activity.

Abstract

Irradiation of amelanotic melanoma B78H1 cells in the presence of liposome-delivered Ni(II)-octabutoxy-naphthalocyanine with a Q-switched Ti:sapphire laser operated in a pulsed mode (850 nm, 30 ns pulses, 10 Hz, 120 mJ pulse -1) promotes a photothermal sensitization process leading to extensive cell inactivation. The photoprocess occurs with identical efficiency in N2-saturated and air-equilibrated media, indicating that this photosensitization modality does not require the presence of oxygen.

• Authors: Monica Camerin, Michael A J Rodgers, Malcolm E Kenney, Giulio Jori
• Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology (Photochem Photobiol Sci) Vol. 4 Issue 3 Pg. 251-3 (Mar 2005) ISSN: 1474-905X [Print] England
• PMID: 15738991 (Publication Type: Journal Article)

Chemical References

• Metalloporphyrins
• octabutoxynaphthalocyaninenickel(II)
• Nitrogen

Topics

• Air
• Animals
• Cell Line, Tumor
• Lasers
• Melanoma, Experimental (drug therapy)
• Metalloporphyrins (therapeutic use)
• Mice
• Nitrogen
• Photochemotherapy (methods)
• Time Factors