Prognostic factors affecting long-term outcome after stem cell transplantation in Hodgkin's lymphoma autografted after a first relapse.

Abstract

PURPOSE:

To analyse outcome and prognostic factors for overall survival (OS) and time to treatment failure (TTF) in 357 patients with Hodgkin's lymphoma (HL) undergoing an autologous stem cell transplantation (ASCT) after a first relapse and reported to the The Grupo Espanol de Linfomas/Trasplante Autologo de Medula Osea (GEL/TAMO) Cooperative Group.

METHODS:

Two hundred and twenty males and 137 females with a median age of 29 years were autografted in second remission (n=181), first sensitive relapse (n=148) and first resistant relapse (n=28).

RESULTS:

Five-year actuarial TTF and OS were of 49% +/- 3% and 57% +/- 3%. Advanced stage at diagnosis, complementary radiotherapy before ASCT, a short first complete response (CR) and detectable disease at ASCT adversely influenced TTF. Year of transplant < or =1995, bulky disease at diagnosis, a short first CR, detectable disease at ASCT and > or =1 extranodal areas involved at ASCT were adverse factors for OS.

CONCLUSIONS:

ASCT constitutes a therapeutic option for HL patients after a first relapse. Promising results are observed in patients with low tumour burden at diagnosis, autografted after a long CR and without detectable disease at ASCT. Innovative approaches should be pursued for patients with risk factors at relapse.

• Authors: A Sureda, M Constans, A Iriondo, R Arranz, M D Caballero, M J Vidal, J Petit, A López, J J Lahuerta, E Carreras, J García-Conde, J García-Laraña, R Cabrera, I Jarque, D Carrera, J C García-Ruiz, M J Pascual, J Rifón, J M Moraleda, K Pérez-Equiza, C Albó, J Díaz-Mediavilla, A Torres, P Torres, J Besalduch, J Marín, M V Mateos, J M Fernández-Rañada, J Sierra, E Conde, Grupo Español de Linfomas/Trasplante Autólogo de Médula Osea Cooperative Group
• Journal: Annals of oncology : official journal of the European Society for Medical Oncology (Ann Oncol) Vol. 16 Issue 4 Pg. 625-33 (Apr 2005) ISSN: 0923-7534 [Print] England
• PMID: 15737986 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adolescent
• Adult
• Aged
• Child
• Female
• Follow-Up Studies
• Hodgkin Disease (diagnosis, prevention & control, therapy)
• Humans
• Male
• Middle Aged
• Neoplasm Recurrence, Local (prevention & control)
• Prognosis
• Stem Cell Transplantation (methods, statistics & numerical data)
• Time
• Transplantation, Autologous
• Treatment Outcome