Abstract | AIMS: METHODS: RESULTS: The results show that lactulose exerted a preventive antiinflammatory effect in this model of rat colitis, as evidenced by a significant reduction of myeloperoxidase activity and by a decrease of both colonic tumor necrosis factor alpha and leukotriene B4 production. This effect was also characterized by an inhibition of colonic inducible nitric oxide synthase expression, which is unregulated as a consequence of the inflammatory status. This beneficial effect was associated with increased levels of lactobacilli and bifidobacteria species in colonic contents in comparison with untreated colitic rats. CONCLUSION:
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Authors | Desiree Camuesco, Laura Peran, Monica Comalada, Ana Nieto, Luiz C Di Stasi, M Elena Rodriguez-Cabezas, Angel Concha, Antonio Zarzuelo, Julio Galvez |
Journal | Inflammatory bowel diseases
(Inflamm Bowel Dis)
Vol. 11
Issue 3
Pg. 265-71
(Mar 2005)
ISSN: 1078-0998 [Print] England |
PMID | 15735433
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Gastrointestinal Agents
- Tumor Necrosis Factor-alpha
- Leukotriene B4
- Lactulose
- Trinitrobenzenesulfonic Acid
- Peroxidase
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Topics |
- Animals
- Colitis
(drug therapy, prevention & control, veterinary)
- Disease Models, Animal
- Female
- Gastrointestinal Agents
(pharmacology)
- Lactobacillaceae
(growth & development)
- Lactulose
(pharmacology)
- Leukotriene B4
(biosynthesis)
- Peroxidase
(pharmacology)
- Rats
- Rats, Wistar
- Trinitrobenzenesulfonic Acid
(administration & dosage, adverse effects)
- Tumor Necrosis Factor-alpha
(biosynthesis)
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