[Association of polymorphisms in testosterone 5-alpha-reductase II genotype and prognosis factors of prostate cancer].

Abstract

OBJECTIVE:

The correlation were studied between testosterone 5-alpha-reductase II (SRD5A2) gene polymorphisms and prognosis factors.

METHODS:

V89L and A49T variants was identified with Mwo1 and Rsa1. The differences of V89L and A49T between cancer of prostate (CaP) and benign prostatic hyperplasia (BPH) were studied. In addition, we also researched the association of polymorphisms with age of onset, free prostate specific antigen (FPSA), total PSA (TPSA), FPSA/TPSA (F/T), Gleason score, and T stage in cancer group.

RESULTS:

We found no differences of V89L and A49T polymorphisms between CaP and BPH. In CaP group the A49T variant was associated with lower age of onset (P = 0.03) and higher Gleason score (P = 0.015). There were no differences between VV and VL+LL polymorphisms with any of the characteristics studied. When the characteristics above were regarded as two-level discrete variable, there were no differences by A49T and V89Lvariants.

CONCLUSION:

In CaP group, the AT+TT genotype was perhaps associated with poor prognosis. VL+LL genotype has no relation with prognosis.

• Authors: Ming Tong, Zhong Xu, Jun-kui Ai, Yi-ming Yuan, Yi Yin, Jun-qi Wang, Hong-wei Li, Jian-he Liu, Dian-qi Xin, Li-qun Zhou, Ming Li, Yan-qun Na
• Journal: Zhonghua wai ke za zhi [Chinese journal of surgery] (Zhonghua Wai Ke Za Zhi) Vol. 42 Issue 24 Pg. 1493-6 (Dec 22 2004) ISSN: 0529-5815 [Print] China
• PMID: 15733480 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 3-Oxo-5-alpha-Steroid 4-Dehydrogenase
• Prostate-Specific Antigen

Topics

• 3-Oxo-5-alpha-Steroid 4-Dehydrogenase (genetics)
• Aged
• Aged, 80 and over
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Humans
• Male
• Middle Aged
• Neoplasm Staging
• Polymorphism, Genetic
• Prognosis
• Prostate-Specific Antigen (blood)
• Prostatic Hyperplasia (genetics)
• Prostatic Neoplasms (blood, genetics, pathology)