A fixed-dose study of alprazolam 2 mg, alprazolam 6 mg, and placebo in panic disorder.

A recently reported multinational, 8-week double-blind, placebo-controlled study assessing the efficacy of alprazolam versus placebo in the treatment of panic disorder indicated significant differences favoring alprazolam. We now report the results of a three-site, 6-week, double-blind, fixed-dose study comparing alprazolam 2 mg, alprazolam 6 mg, and placebo in 94 patients with panic disorder with or without agoraphobia. Both alprazolam treatment groups (6 mg and 2 mg) improved significantly more than did the placebo treatment group on most outcome measures. Only a few statistically significant differences between the 6 mg and 2 mg alprazolam groups were discerned, although the pattern of treatment response across measures suggested a dose effect. Dropouts in the placebo group were primarily due to lack of efficacy and in the alprazolam 6 mg group were due to side effects, which may have contributed to the limited differences between groups at study end. The findings suggest that many patients may require less than 6 mg of alprazolam per day for effective treatment of panic disorder.
AuthorsR B Lydiard, I M Lesser, J C Ballenger, R T Rubin, M Laraia, R DuPont
JournalJournal of clinical psychopharmacology (J Clin Psychopharmacol) Vol. 12 Issue 2 Pg. 96-103 (Apr 1992) ISSN: 0271-0749 [Print] UNITED STATES
PMID1573046 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Alprazolam
  • Adolescent
  • Adult
  • Aged
  • Agoraphobia (blood, drug therapy, psychology)
  • Alprazolam (administration & dosage, adverse effects, pharmacokinetics)
  • Arousal (drug effects)
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neurologic Examination
  • Panic Disorder (blood, drug therapy, psychology)
  • Personality Assessment

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