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Hypotensive and lipid regulatory actions of 4-hydroxyderricin, a chalcone from Angelica keiskei, in stroke-prone spontaneously hypertensive rats.

Abstract
1. Previously, we found that Angelica keiskei extract (ethyl acetate extract from the yellow liquid of stems) elevated serum high-density lipoprotein (HDL) levels and reduced liver triglyceride content in stroke-prone spontaneously hypertensive rats (SHRSP). To identify the active substance in A. keiskei extract, we examined the effect of 4-hydroxyderricin, a characteristic chalcone isolated from the yellow liquid of stems, on blood pressure and lipid metabolism in SHRSP. 2. Six-week-old male SHRSP were fed diets containing 0.07% 4-hydroxyderricin for 7 weeks with free access to the diet and water. Elevation of systolic blood pressure was significantly suppressed after 7 weeks treatment. Serum very low-density lipoprotein (VLDL) levels were significantly reduced, without any effect on HDL levels, and were associated with a significant decrease in the serum concentration of free fatty acids. 3. In the liver, significant decreases in relative liver weight and triglyceride content were found after treatment with 4-hydroxyderricin for 7 weeks. 4. An investigation of hepatic mRNA expression of proteins involved in lipid metabolism indicated that a significant decrease in microsomal triglyceride transferprotein may be responsible for the decrease in serum VLDL levels and that significant decreases in adipocyte determination and differentiation factor 1 and fatty acid synthase may be responsible for the decrease in hepatic triglyceride content. 5. In conclusion, dietary 4-hydroxyderricin produces suppression of the elevation of systolic blood pressure, reduction of serum VLDL levels and a decrease in hepatic triglyceride content in SHRSP.
AuthorsHiroshi Ogawa, Mami Ohno, Kimiye Baba
JournalClinical and experimental pharmacology & physiology (Clin Exp Pharmacol Physiol) 2005 Jan-Feb Vol. 32 Issue 1-2 Pg. 19-23 ISSN: 0305-1870 [Print] Australia
PMID15730429 (Publication Type: Journal Article)
Chemical References
  • Antihypertensive Agents
  • Apolipoproteins
  • Enzyme Inhibitors
  • Hypolipidemic Agents
  • Lipoproteins
  • Plant Extracts
  • RNA, Messenger
  • 4-hydroxyderricin
  • Chalcone
  • Cholesterol 7-alpha-Hydroxylase
Topics
  • Angelica (chemistry)
  • Animals
  • Antihypertensive Agents
  • Apolipoproteins (blood, chemistry)
  • Blood Pressure (drug effects)
  • Chalcone (analogs & derivatives, pharmacology)
  • Cholesterol 7-alpha-Hydroxylase (antagonists & inhibitors, metabolism)
  • Diet
  • Enzyme Inhibitors (pharmacology)
  • Hypolipidemic Agents
  • Lipid Metabolism
  • Lipoproteins (blood, chemistry)
  • Liver (drug effects, enzymology, metabolism)
  • Male
  • Microsomes, Liver (enzymology, metabolism)
  • Organ Size (drug effects)
  • Plant Extracts (therapeutic use)
  • Plant Stems (chemistry)
  • RNA, Messenger (biosynthesis)
  • Rats
  • Rats, Inbred SHR
  • Reverse Transcriptase Polymerase Chain Reaction

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