Abstract |
A strain of Streptomyces nodosus (NPS007994) isolated from a marine sediment collected in Scripps Canyon, La Jolla, California, was found to produce lajollamycin (1), a nitro-tetraene spiro-beta- lactone-gamma- lactam antibiotic. The structure was established by complete analysis of spectroscopic data and comparison with known antibiotics oxazolomycin (2), 16-methyloxazolomycin (3), and triedimycin B (4). Lajollamycin (1) showed antimicrobial activity against both drug-sensitive and -resistant Gram-positive bacteria and inhibited the growth of B16-F10 tumor cells in vitro.
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Authors | Rama Rao Manam, Sy Teisan, Donald J White, Benjamin Nicholson, Jennifer Grodberg, Saskia T C Neuteboom, Kin S Lam, Deborah A Mosca, G Kenneth Lloyd, Barbara C M Potts |
Journal | Journal of natural products
(J Nat Prod)
Vol. 68
Issue 2
Pg. 240-3
(Feb 2005)
ISSN: 0163-3864 [Print] United States |
PMID | 15730252
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Antineoplastic Agents
- Lactams
- Oxazoles
- Polyunsaturated Alkamides
- Spiro Compounds
- lajollamycin
- curromycin B
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Topics |
- Animals
- Anti-Bacterial Agents
(chemistry, isolation & purification, pharmacology)
- Antineoplastic Agents
(chemistry, isolation & purification, pharmacology)
- California
- Cell Line, Tumor
- Drug Screening Assays, Antitumor
- Gram-Positive Bacteria
(drug effects)
- Lactams
(chemistry, isolation & purification, pharmacology)
- Mice
- Microbial Sensitivity Tests
- Molecular Structure
- Oxazoles
(chemistry)
- Polyunsaturated Alkamides
- Spiro Compounds
(chemistry, isolation & purification, pharmacology)
- Streptomyces
(chemistry)
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