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Lajollamycin, a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic from the marine actinomycete Streptomyces nodosus.

Abstract
A strain of Streptomyces nodosus (NPS007994) isolated from a marine sediment collected in Scripps Canyon, La Jolla, California, was found to produce lajollamycin (1), a nitro-tetraene spiro-beta-lactone-gamma-lactam antibiotic. The structure was established by complete analysis of spectroscopic data and comparison with known antibiotics oxazolomycin (2), 16-methyloxazolomycin (3), and triedimycin B (4). Lajollamycin (1) showed antimicrobial activity against both drug-sensitive and -resistant Gram-positive bacteria and inhibited the growth of B16-F10 tumor cells in vitro.
AuthorsRama Rao Manam, Sy Teisan, Donald J White, Benjamin Nicholson, Jennifer Grodberg, Saskia T C Neuteboom, Kin S Lam, Deborah A Mosca, G Kenneth Lloyd, Barbara C M Potts
JournalJournal of natural products (J Nat Prod) Vol. 68 Issue 2 Pg. 240-3 (Feb 2005) ISSN: 0163-3864 [Print] United States
PMID15730252 (Publication Type: Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Lactams
  • Oxazoles
  • Polyunsaturated Alkamides
  • Spiro Compounds
  • lajollamycin
  • curromycin B
Topics
  • Animals
  • Anti-Bacterial Agents (chemistry, isolation & purification, pharmacology)
  • Antineoplastic Agents (chemistry, isolation & purification, pharmacology)
  • California
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Gram-Positive Bacteria (drug effects)
  • Lactams (chemistry, isolation & purification, pharmacology)
  • Mice
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Oxazoles (chemistry)
  • Polyunsaturated Alkamides
  • Spiro Compounds (chemistry, isolation & purification, pharmacology)
  • Streptomyces (chemistry)

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