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Immune complex disease associated with Peroben intake.

Abstract
The clinical history and biological investigations of a patient presenting an immune complex disease induced by Peroben are reported. Biological signs were those of a drug-induced lupus syndrome. A provocation test allowed disclosure of its pathomechanism, since during Peroben intake a high C1q binding activity occurred and later regressed, while deposits of IgM and C3 were evidenced in the vessel walls. Complete or partial thrombosis succeeded accompanying a leukocytoclastic vasculitis.
AuthorsD Van Neste, G E Piérard, J F Hermanns
JournalDermatologica (Dermatologica) Vol. 158 Issue 6 Pg. 417-26 ( 1979) ISSN: 0011-9075 [Print] Switzerland
PMID157301 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Complement C3
  • Drug Combinations
  • Hypnotics and Sedatives
  • Immunoglobulin M
  • Pyridones
  • peroben
  • Diphenhydramine
Topics
  • Adult
  • Complement C3 (analysis)
  • Diphenhydramine (adverse effects)
  • Drug Combinations
  • Female
  • Humans
  • Hypnotics and Sedatives (adverse effects)
  • Immune Complex Diseases (chemically induced, pathology)
  • Immunoglobulin M (analysis)
  • Lupus Erythematosus, Systemic (chemically induced)
  • Pyridones (adverse effects)
  • Skin (pathology)
  • Skin Tests
  • Thrombosis (chemically induced)
  • Vasculitis (chemically induced)

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