Abstract | AIM: The aim of this study was to develop a novel approach to the analysis of bone histomorphometric data and outcomes presentation that would simplify the characterization of renal osteodystrophy and facilitate clinical decision-making. METHODS AND MATERIALS: Data were derived from a randomized trial of dialysis patients treated for one year with a dose of lanthanum carbonate or calcium carbonate (up to 3750 mg/day and 9000 mg/day, respectively). Histomorphometric analyses of baseline and end-of-study bicortical transiliac bone biopsies were performed. Activation frequency, bone formation rate/bone surface, osteoclast surface/ bone surface, osteoblast surface/bone surface, mineralization lag time, and osteoid thickness were determined to provide a measure of overall bone cell activity (bone formation, bone resorption, bone turnover) and risk of developing osteopenia (bone balance). A novel approach of qualitatively grouping these numerical data as "improved", "unchanged", or "worsened" based on deviation from normal was used to facilitate interpretation of clinical relevance. RESULTS: CONCLUSIONS:
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Authors | T Freemont, H H Malluche |
Journal | Clinical nephrology
(Clin Nephrol)
Vol. 63
Issue 2
Pg. 138-45
(Feb 2005)
ISSN: 0301-0430 [Print] Germany |
PMID | 15730056
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Lanthanum
- Calcium Carbonate
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Topics |
- Adult
- Bone Remodeling
(drug effects, physiology)
- Calcification, Physiologic
(drug effects, physiology)
- Calcium Carbonate
(pharmacology)
- Chronic Kidney Disease-Mineral and Bone Disorder
(pathology, physiopathology)
- Female
- Histological Techniques
(methods)
- Humans
- Ilium
(drug effects, pathology, physiopathology)
- Lanthanum
(pharmacology)
- Male
- Osteocytes
(drug effects, physiology)
- Prospective Studies
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