The effect of betahistine, a histamine H1 receptor agonist/H3 antagonist, on olanzapine-induced weight gain in first-episode schizophrenia patients.

Histamine antagonism has been implicated in antipsychotic drug-induced weight gain. Betahistine, a histamine enhancer with H1 agonistic/H3 antagonistic properties (48 mg t.i.d.), was coadministered with olanzapine (10 mg/day) in three first-episode schizophrenia patients for 6 weeks. Body weight was measured at baseline and weekly thereafter. Clinical rating scales were completed at baseline and at week 6. All participants gained weight (mean weight gain 3.1+/-0.9 kg) and a similar pattern of weight gain was observed: an increase during the first 2 weeks and no additional weight gain (two patients) or minor weight loss (one patient) from weeks 3 to 6. None gained 7% of baseline weight, which is the cut-off for clinically significant weight gain. Betahistine was safe and well tolerated and did not interfere with the antipsychotic effect of olanzapine. Our findings justify a placebo-controlled evaluation of the putative weight-attenuating effect of betahistine in olanzapine-induced weight gain.
AuthorsMichael Poyurovsky, Artashes Pashinian, Aya Levi, Ronit Weizman, Abraham Weizman
JournalInternational clinical psychopharmacology (Int Clin Psychopharmacol) Vol. 20 Issue 2 Pg. 101-3 (Mar 2005) ISSN: 0268-1315 [Print] England
PMID15729086 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Antipsychotic Agents
  • Histamine Agonists
  • Histamine Antagonists
  • Receptors, Histamine H3
  • Benzodiazepines
  • olanzapine
  • Betahistine
  • Adult
  • Antipsychotic Agents (adverse effects, therapeutic use)
  • Benzodiazepines (adverse effects, therapeutic use)
  • Betahistine (pharmacology)
  • Body Mass Index
  • Body Weight (drug effects)
  • Histamine Agonists (pharmacology)
  • Histamine Antagonists (pharmacology)
  • Humans
  • Receptors, Histamine H3 (drug effects)
  • Schizophrenia (complications, drug therapy)
  • Weight Gain (drug effects)

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