Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial.

Abstract

Riboflavin, which improves energy metabolism similarly to coenzyme Q10 (CoQ10), is effective in migraine prophylaxis. We compared CoQ10 (3 x 100 mg/day) and placebo in 42 migraine patients in a double-blind, randomized, placebo-controlled trial. CoQ10 was superior to placebo for attack-frequency, headache-days and days-with-nausea in the third treatment month and well tolerated; 50%-responder-rate for attack frequency was 14.4% for placebo and 47.6% for CoQ10 (number-needed-to-treat: 3). CoQ10 is efficacious and well tolerated.

• Authors: P S Sándor, L Di Clemente, G Coppola, U Saenger, A Fumal, D Magis, L Seidel, R M Agosti, J Schoenen
• Journal: Neurology (Neurology) Vol. 64 Issue 4 Pg. 713-5 (Feb 22 2005) ISSN: 1526-632X [Electronic] United States
• PMID: 15728298 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Ubiquinone

Topics

• Adult
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Migraine Disorders (prevention & control)
• Treatment Outcome
• Ubiquinone (therapeutic use)