Abstract | BACKGROUND: METHODS: The presence of secretoneurin in nasal biopsies and its release in response to nasal capsaicin and histamine challenges were examined. Symptoms and lavage fluid levels of fucose were recorded as markers of effects in part produced by neural activity. Bronchial histamine challenges followed by sputum induction and analysis of secretoneurin were also carried out. RESULTS: CONCLUSIONS: We conclude that secretoneurin is present in healthy human airways and that histamine evokes its release in both nasal and bronchial mucosae. The present observations support the possibility that secretoneurin is involved in histamine-dependent responses of the human airway mucosa.
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Authors | M Korsgren, R Fischer-Colbrie, M Andersson, W B Coman, A Mackay-Sim, C G Persson, F Sundler, B Wallwork, L Greiff |
Journal | Allergy
(Allergy)
Vol. 60
Issue 4
Pg. 459-63
(Apr 2005)
ISSN: 0105-4538 [Print] Denmark |
PMID | 15727576
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Neuropeptides
- Secretogranin II
- secretoneurin
- Fucose
- Histamine
- Capsaicin
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Topics |
- Administration, Topical
- Adult
- Bronchi
(drug effects, metabolism)
- Bronchial Provocation Tests
- Capsaicin
(administration & dosage, pharmacology)
- Fucose
(metabolism)
- Histamine
(administration & dosage, pharmacology)
- Humans
- Nasal Mucosa
(drug effects, innervation, metabolism)
- Nasal Provocation Tests
- Nervous System
(metabolism)
- Neuropeptides
(metabolism)
- Reference Values
- Respiratory Mucosa
(drug effects, metabolism)
- Secretogranin II
- Tissue Distribution
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