Genetic mapping on the mouse X chromosome of human cDNA clones for the fragile X and Hunter syndromes.

Abstract

Murine X-linked genes corresponding to the human Fragile X (FMR1) and Hunter syndrome (IDS) loci have been mapped in an interspecific backcross between B6CBA-Aw-J/A-Bpa and Mus spretus using human cDNA clones. Pedigree analysis of recombinants from a total of 248 backcross progeny favors a gene order of (Cf-9, Mcf-2)-(Fmr-1)-Ids-Gabra3-Rsvp. Gene order is conserved between the species, although no fragile site has been detected in the mouse in this region of the murine X chromosome.

• Authors: C J Faust, A J Verkerk, P J Wilson, C P Morris, J J Hopwood, B A Oostra, G E Herman
• Journal: Genomics (Genomics) Vol. 12 Issue 4 Pg. 814-7 (Apr 1992) ISSN: 0888-7543 [Print] United States
• PMID: 1572654 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• DNA

Topics

• Animals
• Chromosome Fragile Sites
• Chromosome Fragility
• Chromosome Mapping
• Crosses, Genetic
• DNA (genetics)
• Female
• Fragile X Syndrome (genetics)
• Humans
• Male
• Mice
• Mucopolysaccharidosis II (genetics)
• Recombination, Genetic
• Species Specificity
• X Chromosome