Allergic contact dermatitis from cocamidopropyl betaine, cocamidoamine, 3-(dimethylamino)propylamine, and oleamidopropyl dimethylamine: co-reactions or cross-reactions?

Abstract	We present the case of a patient with facial dermatitis caused by sensitization to cocamidopropyl betaine. The patient also had positive patch-test reactions to cocamidoamine, 3-(dimethylamino)propylamine, and oleamidopropyl dimethylamine. The presence of 3-(dimethylamino)propylamine as an impurity in all of these substances can be hypothesized to explain these simultaneous reactions.
Authors	Linda Moreau, Denis Sasseville
Journal	Dermatitis : contact, atopic, occupational, drug (Dermatitis) Vol. 15 Issue 3 Pg. 146-9 (Sep 2004) ISSN: 1710-3568 [Print] United States
PMID	15724349 (Publication Type: Case Reports, Journal Article)
Chemical References	Allergens Cosmetics Diamines Hair Preparations Propylamines Surface-Active Agents N-(3-(dimethylamino)propyl)oleamide Betaine cocamidopropyl betaine 3-dimethylaminopropylamine
Topics	Adult Allergens (adverse effects) Betaine (adverse effects, analogs & derivatives) Cosmetics (adverse effects) Cross Reactions Dermatitis, Allergic Contact (etiology) Diamines (adverse effects) Drug Synergism Female Hair Preparations (adverse effects) Humans Propylamines (adverse effects) Surface-Active Agents (adverse effects)

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