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New drugs for colorectal cancer (irinotecan, oxaliplatin, raltitrexed) meet expectations in routine practice: a single center's experience before and after their introduction.

AbstractBACKGROUND AND AIMS:
Treatment of metastatic colorectal cancer with new drugs (NDs) as oxaliplatin and irinotecan had improved response and survival. In order to check whether the promising achievements of the trials are obtained in routine clinical practice, we have reviewed retrospectively our results for two periods, before (period A: 1993-1995, n=63) and after (period B:1998-2000 n=103) the introduction of these NDs. Patients characteristics, treatment modalities, survival, and prognostic factors were compared.
PATIENTS:
There were 74 women and 92 men, aged 60.8+/-11.6 yr, 7 patients received best supportive care only, 91 had synchronous metastasis.
RESULTS:
Period B patients were older, with WHO score>1 more often, more adjuvant treatment, more metachronous metastasis, and NDs used more frequently (24% vs 59%). Median survival was similar (16 vs 15 mo). But when looking at the population aged<75 years with WHO score<2, median survival was 13 mo (period A) vs 21 mo (period B); survival at 1, 2, and 3 yr were respectively 59.5+/-8%, 16.2+/-6 %, 13.5+/-6 % vs 69.8+/-6%, 49.6+/-7%, 29.8+/-7%, p<0.01). In multiparametric analysis, factors correlated with survival were the absence of elevated serum alkaline phosphatase, a unique metastatic organ, and administration of NDs.
CONCLUSION:
In our routine clinical experience the use of NDs for metastatic CRC has allowed a significant improvement in survival among patients with unresectable tumors.
AuthorsJoëlle Egreteau, Eveline Boucher, Sophie de Guibert, Christian Jacquelinet, Bernard Meunier, Karim Boudjema, Jean-Luc Raoul
JournalInternational journal of gastrointestinal cancer (Int J Gastrointest Cancer) Vol. 35 Issue 1 Pg. 69-76 ( 2005) ISSN: 1537-3649 [Print] United States
PMID15722576 (Publication Type: Journal Article)
Chemical References
  • Antimetabolites, Antineoplastic
  • Antineoplastic Agents
  • Antineoplastic Agents, Phytogenic
  • Organoplatinum Compounds
  • Quinazolines
  • Thiophenes
  • Oxaliplatin
  • Irinotecan
  • raltitrexed
  • Camptothecin
Topics
  • Age Factors
  • Aged
  • Antimetabolites, Antineoplastic (therapeutic use)
  • Antineoplastic Agents (therapeutic use)
  • Antineoplastic Agents, Phytogenic (therapeutic use)
  • Camptothecin (analogs & derivatives, therapeutic use)
  • Colorectal Neoplasms (drug therapy)
  • Evidence-Based Medicine
  • Female
  • Humans
  • Irinotecan
  • Male
  • Medical Oncology (statistics & numerical data)
  • Middle Aged
  • Organoplatinum Compounds (therapeutic use)
  • Oxaliplatin
  • Prognosis
  • Quinazolines (therapeutic use)
  • Retrospective Studies
  • Survival Analysis
  • Thiophenes (therapeutic use)
  • Treatment Outcome

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