Phenidone, a dual inhibitor of cyclooxygenases and lipoxygenases, ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its target enzymes.
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| Abstract |
This study examined whether phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), affects the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in the rat, and the expression of both COX-1/-2 and 5-LOX in EAE spinal cords. Oral phenidone (200 mg/kg) significantly suppressed the incidence and clinical severity of EAE paralysis. Western blot analysis showed that phenidone significantly inhibited the increases in COX-1/-2 and 5-LOX in the spinal cords of rats with EAE. This finding was paralleled by immunohistochemical observations. Overall, these findings suggest that COX-1/-2 and 5-LOX are important inflammatory mediators in the pathogenesis of EAE, and that the inhibition of both COX and LOX ameliorates the autoimmune disorder of the central nervous system.
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| Authors | Changjong Moon, Meejung Ahn, Myung-Bok Wie, Hyung-Min Kim, Chang-Sung Koh, Seong-Chul Hong, Moon-Doo Kim, Naoyuki Tanuma, Yoh Matsumoto, Taekyun Shin |
| Journal | Brain research (Brain Res) Vol. 1035 Issue 2 Pg. 206-10 (Feb 28 2005) ISSN: 0006-8993 [Print] Netherlands |
| PMID | 15722060 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't) |
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