Maternal exposure to androstenedione does not induce developmental toxicity in the rat.

Abstract

Thirty-day old female rats received corn oil or androstenedione (in corn oil) at one of four concentrations (5.0, 10.0, 30.0 or 60.0 mg/kg body weight) by gavage for two weeks prior to mating, during the mating period and until gestation day (GD) 19. Caesarean sections were performed on GD 20. No dose related changes were observed in serum androstenedione, estradiol, LH, FSH, testosterone or progesterone. A statistically significant decrease in estrous cycle length was observed in the 60.0 mg/kg dose group only. Feed and fluid consumption, mean body weight gain, organ weight and fetal parameters were not affected by androstenedione treatment. At the doses given, androstenedione had no specific effect on the development of individual bones or soft tissues.

• Authors: Robert L Sprando, Thomas F X Collins, Thomas N Black, Nicholas Olejnik, Philip Sapienza, Moraima Ramos-Valle, Dennis I Ruggles
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 43 Issue 4 Pg. 505-13 (Apr 2005) ISSN: 0278-6915 [Print] England
• PMID: 15721196 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Androstenedione

Topics

• Administration, Oral
• Androstenedione (toxicity)
• Animals
• Bone and Bones (embryology)
• Dose-Response Relationship, Drug
• Estrus (drug effects, physiology)
• Female
• Fetal Development (drug effects)
• Male
• Maternal-Fetal Exchange
• Pregnancy
• Rats