Ex vivo measures of LDL oxidative susceptibility predict carotid artery disease.

Abstract

AIM:

The purpose of the study was to assess whether ex vivo measures of low-density lipoprotein (LDL) oxidation improved prediction of carotid artery disease (CAAD) case-control status compared to standard lipid and smoking measures.

METHODS:

One hundred and forty cases with a high degree of carotid artery stenosis aged 40-83 years and an equal number of controls without stenosis or other vascular disease were matched by censored age within 2 years. Matched logistic regression evaluated the significance of copper-induced oxidative measures with and without covariates. The relationship of LDL oxidation measures with statin use and current smoking was also evaluated.

RESULTS:

Logistic regression demonstrated a significant effect of the three correlated measures of oxidative susceptibility (lag time, oxidation rate and maximal rate of oxidation) separately on disease prediction (all p<0.05). These oxidative measures remained significant predictors of case-control status when other cardiovascular disease predictors (age; LDL-C, HDL-C and ApoAI levels; current smoking, ever smoking and pack-years smoked) were jointly considered. This relationship was not attributable to the effects of statin use on LDL oxidation.

CONCLUSIONS:

Ex vivo measures of oxidation improved the prediction of carotid artery disease status, suggesting that this is an important determinant of atherosclerotic risk in this older population.

• Authors: Audrey Hendrickson, Laura A McKinstry, Julieann K Lewis, Jeremy Lum, Andy Louie, Gerard D Schellenberg, Thomas S Hatsukami, Alan Chait, Gail P Jarvik
• Journal: Atherosclerosis (Atherosclerosis) Vol. 179 Issue 1 Pg. 147-53 (Mar 2005) ISSN: 0021-9150 [Print] Ireland
• PMID: 15721021 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cholesterol, LDL

Topics

• Adult
• Aged
• Aged, 80 and over
• Carotid Artery Diseases (diagnosis, epidemiology, metabolism)
• Carotid Stenosis (diagnosis, epidemiology, metabolism)
• Case-Control Studies
• Cholesterol, LDL (metabolism)
• Humans
• Logistic Models
• Male
• Middle Aged
• Oxidation-Reduction
• Predictive Value of Tests
• Risk Factors
• Smoking (epidemiology)