Abstract | OBJECTIVE: METHODS: Data from the double-blind placebo-controlled ACTION trial was stratified for hypertension (blood pressure > or = 140/90 mmHg), at baseline. RESULTS: A total of 52% of 7665 ACTION patients were hypertensive. Some 80% were on a beta blocker; hypertensives were more often treated with other blood pressure-lowering drugs. Mean baseline blood pressure was 122/74 mmHg among normotensives and 151/85 mmHg among hypertensives. Follow-up blood pressures were reduced by nifedipine (P < 0.001) on the average by 3.9/2.4 and 6.6/3.5 mmHg among normotensives and hypertensives, respectively. Nifedipine GITS significantly (P < 0.05) reduced the combined incidence of all-cause mortality, myocardial infarction, refractory angina, heart failure, stroke and peripheral revascularization by 13% in hypertensives only. Nifedipine significantly reduced the incidence of any stroke or transient ischemic attack by almost 30% in both subgroups and the need for coronary angiography by 21% in normotensives and 16% in hypertensives. Among hypertensives, the incidence of new overt heart failure was significantly reduced by 38% and of debilitating stroke by 33%. Among normotensives, the need for coronary bypass grafting was significantly reduced by 32%. Nifedipine did not affect all-cause death, cardiovascular death and myocardial infarction in either normo- or hypertensives, but increased the need for peripheral revascularization. CONCLUSION:
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Authors | Jacobus Lubsen, Gilbert Wagener, Bridget-Anne Kirwan, Sophie de Brouwer, Philip A Poole-Wilson, ACTION (A Coronary disease Trial Investigating Outcome with Nifedipine GITS) investigators |
Journal | Journal of hypertension
(J Hypertens)
Vol. 23
Issue 3
Pg. 641-8
(Mar 2005)
ISSN: 0263-6352 [Print] England |
PMID | 15716708
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic beta-Antagonists
- Calcium Channel Blockers
- Nifedipine
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Topics |
- Adrenergic beta-Antagonists
(administration & dosage)
- Aged
- Angina Pectoris
(drug therapy, mortality)
- Blood Pressure
(drug effects)
- Calcium Channel Blockers
(administration & dosage)
- Coronary Artery Disease
(drug therapy, mortality)
- Drug Therapy, Combination
- Female
- Humans
- Hypertension
(drug therapy, mortality)
- Incidence
- Male
- Middle Aged
- Morbidity
- Nifedipine
(administration & dosage)
- Risk Factors
- Stroke
(drug therapy, mortality)
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