Role of endogenous platelet-activating factor in caerulein-induced acute pancreatitis in rats: protective effects of a PAF-antagonist.

Abstract

The role of endogenous platelet-activating factor (PAF) in the pathogenesis of acute pancreatitis was investigated by determining whether CV-6209, a selective PAF antagonist, confers protection against caerulein-induced acute pancreatitis in rats. Continuous intravenous infusion of caerulein (5 micrograms/kg x h) induced time-dependent increase in serum pancreatic enzymes, pancreatic weight, and protein content of the pancreas, and produced histologic evidence of acute pancreatitis. Pretreatment with CV-6209 (1 mg/kg) significantly inhibited the elevation of serum pancreatic enzymes, pancreatic weight, and protein content of the pancreas. Caerulein-induced tissue oedema and recruitment of leucocytic cells were markedly ameliorated with CV-6209. Platelet-activating factor may be released endogenously and may play a role during acute pancreatitis.

• Authors: K Fujimura, Y Kubota, M Ogura, T Yamaguchi, T Binnaka, K Tani, S Kitagawa, T Mizuno, K Inoue
• Journal: Journal of gastroenterology and hepatology (J Gastroenterol Hepatol) 1992 Mar-Apr Vol. 7 Issue 2 Pg. 199-202 ISSN: 0815-9319 [Print] Australia
• PMID: 1571504 (Publication Type: Journal Article)

Chemical References

• Platelet Activating Factor
• Pyridinium Compounds
• CV 6209
• Ceruletide

Topics

• Acute Disease
• Animals
• Ceruletide
• Male
• Organ Size (drug effects)
• Pancreas (enzymology, pathology)
• Pancreatitis (chemically induced, enzymology, pathology, physiopathology)
• Platelet Activating Factor (antagonists & inhibitors, physiology)
• Pyridinium Compounds (pharmacology)
• Rats
• Rats, Inbred Strains