HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Immunoglobulin replacement therapy in primary antibody deficiency diseases--maximizing success.

Abstract
Antibody or humoral immunodeficiencies comprise the largest group of primary immunodeficiency diseases. Since the first description of patients with low gammaglobulin levels more than four decades ago, a great wealth of information has been accumulated. Especially in the last several years, the application of molecular and genetic techniques has unraveled many of these disorders, identifying disorders of B cell development, failure of class switch recombination and abnormalities of specific antibody production. Regardless of the underlying defect, the mainstay of therapy has been and remains immunoglobulin (Ig) replacement therapy, currently by intravenous infusion or subcutaneous injection. With advances in manufacturing, a number of products are not only safe for intravenous administration but doses can be increased to provide even more effective infection prophylaxis. However, manufacturing processes, methods of viral inactivation and removal and final composition differ widely among the available preparations. How these variables impact clinical outcome is not clear, but they have the potential to do so. As a result, careful selection of an intravenous immunoglobulin (IVIG), matching patient needs and risks to those risks associated with a specific IVIG, is necessary to optimize outcomes and maximize the success of Ig replacement therapy.
AuthorsAnne Durandy, Volker Wahn, Steve Petteway, Erwin W Gelfand
JournalInternational archives of allergy and immunology (Int Arch Allergy Immunol) Vol. 136 Issue 3 Pg. 217-29 (Mar 2005) ISSN: 1018-2438 [Print] Switzerland
PMID15713984 (Publication Type: Journal Article, Review)
CopyrightCopyright (c) 2005 S. Karger AG, Basel.
Chemical References
  • Immunoglobulins, Intravenous
Topics
  • Antibody Formation
  • B-Lymphocytes (immunology, pathology)
  • Cell Differentiation (immunology)
  • Disease Transmission, Infectious (prevention & control)
  • Humans
  • Immunoglobulins, Intravenous (adverse effects, therapeutic use)
  • Immunologic Deficiency Syndromes (therapy)
  • Risk
  • Virus Inactivation

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: