Abstract | OBJECTIVE: DESIGN AND SETTING: Prospective, randomized, controlled study in the pulmonary pediatric department of a university hospital. PATIENTS: INTERVENTIONS: Breathing pattern and respiratory effort were measured by esophageal and transdiaphragmatic pressure monitoring during spontaneous breathing, with or without CPAP and BIPAP ventilation. MEASUREMENTS AND RESULTS: Median respiratory rate decreased from 45 breaths/min (range 24-84) during spontaneous breathing to 29 (range 18-60) during CPAP ventilation. All indices of respiratory effort decreased significantly during CPAP ventilation compared to unassisted spontaneous breathing (median, range): esophageal pressure swing from 28 to 10 cmH(2)O (13-76 to 7-28), esophageal pressure time product from 695 to 143 cmH(2)O/s per minute (264-1417 to 98-469), diaphragmatic pressure time product from 845 to 195 cmH(2)O/s per minute (264-1417 to 159-1183) During BIPAP ventilation a similar decrease in respiratory effort was observed but with patient-ventilator asynchrony in all patients. CONCLUSIONS: This short-term study shows that noninvasive CPAP and BIPAP ventilation are associated with a significant and comparable decrease in respiratory effort in infants with upper airway obstruction. However, BIPAP ventilation was associated with patient-ventilator asynchrony.
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Authors | Sandrine Essouri, Frédéric Nicot, Annick Clément, Erea-Noel Garabedian, Gilles Roger, Frédéric Lofaso, Brigitte Fauroux |
Journal | Intensive care medicine
(Intensive Care Med)
Vol. 31
Issue 4
Pg. 574-80
(Apr 2005)
ISSN: 0342-4642 [Print] United States |
PMID | 15711977
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Topics |
- Airway Obstruction
(therapy)
- Continuous Positive Airway Pressure
(methods)
- Female
- France
- Humans
- Infant
- Intensive Care Units, Pediatric
- Laryngeal Masks
- Male
- Monitoring, Physiologic
- Oxygen Inhalation Therapy
- Prospective Studies
- Treatment Outcome
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