Update on branched-chain amino acid supplementation in liver diseases.

Abstract

PURPOSE OF REVIEW:

Branched-chain amino acids (BCAAs) have a peculiar role in whole-body nitrogen metabolism. BCAAs are a substrate for protein synthesis, and have been used to conserve or restore muscle mass in advanced liver disease. In addition, the competitive action of BCAAs on amino acid transport across the blood-brain barrier may improve hepatic encephalopathy.

RECENT FINDINGS:

The effects of branched-chain amino acids on nutrition and ultimately on prognosis of patients with advanced cirrhosis have been confirmed in a large multicenter, long-term trial. Similarly, BCAA treatment improved the prognosis of patients with hepatocellular carcinoma, treated by chemoembolization. The mechanism for the beneficial effects of BCAA is likely to depend on the stimulating activity of BCAA on hepatocyte growth factor, favoring liver regeneration.

SUMMARY:

After an experience of 25 years with branched-chain amino acids, new data supports their beneficial effect in liver diseases. Although the number of patients who cannot tolerate dietary proteins in amounts sufficient to meet their increased catabolism is probably low, in this specific setting BCAAs remain the sole treatment of proved efficacy.

• Authors: Giampaolo Bianchi, Rebecca Marzocchi, Federica Agostini, Giulio Marchesini
• Journal: Current opinion in gastroenterology (Curr Opin Gastroenterol) Vol. 21 Issue 2 Pg. 197-200 (Mar 2005) ISSN: 0267-1379 [Print] United States
• PMID: 15711213 (Publication Type: Journal Article, Review)

Chemical References

• Amino Acids, Branched-Chain

Topics

• Amino Acids, Branched-Chain (therapeutic use)
• Chronotherapy
• Humans
• Liver Diseases (drug therapy)