Antibody titer to gp210-C terminal peptide as a clinical parameter for monitoring primary biliary cirrhosis.

Abstract

BACKGROUND/AIMS:

The presence of antibodies to the 210-kDa glycoprotein of the nuclear pore complex (gp210) is highly indicative of primary biliary cirrhosis (PBC). However, the significance of anti-gp210 antibody titers for monitoring PBC remains unresolved.

METHODS:

We used an ELISA with a gp210 C-terminal peptide as an antigen to assess serum antibody titers in 71 patients with PBC.

RESULTS:

Patients were classified into three groups: Group A in whom anti-gp210 titers were sustained at a high level, Group B in whom anti-gp210 status changed from positive to negative under ursodeoxycholic acid (UDCA) therapy, Group C in whom anti-gp210 antibodies were negative at the time of diagnosis. The rate of progression to end-stage hepatic failure was significantly higher in group A (60%) as compared to groups B (0%) and C (4.2%). The sustained antibody response to gp210 was closely associated with the severity of interface hepatitis. The significance of anti-gp210 antibody was confirmed by National Hospital Organization Study Group for Liver Disease in Japan.

CONCLUSIONS:

The serial quantitation of serum anti-gp210-C-terminal peptide antibodies is useful for monitoring the effect of UDCA and for the early identification of patients at high risk for end-stage hepatic failure.

• Authors: Minoru Nakamura, Yuki Shimizu-Yoshida, Yasushi Takii, Atsumasa Komori, Terufumi Yokoyama, Toshihito Ueki, Manabu Daikoku, Koji Yano, Takehiro Matsumoto, Kiyoshi Migita, Hiroshi Yatsuhashi, Masahiro Ito, Naohiko Masaki, Hiroshi Adachi, Yukio Watanabe, Yoko Nakamura, Takeo Saoshiro, Takeshi Sodeyama, Michiaki Koga, Shinji Shimoda, Hiromi Ishibashi
• Journal: Journal of hepatology (J Hepatol) Vol. 42 Issue 3 Pg. 386-92 (Mar 2005) ISSN: 0168-8278 [Print] Netherlands
• PMID: 15710222 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies
• Biomarkers
• Membrane Glycoproteins
• NUP210 protein, human
• Nuclear Pore Complex Proteins
• Nuclear Proteins
• Peptide Fragments
• Ursodeoxycholic Acid

Topics

• Antibodies (blood)
• Biomarkers (blood)
• Disease-Free Survival
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Liver Cirrhosis, Biliary (blood, immunology, mortality, therapy)
• Liver Function Tests
• Liver Transplantation (physiology)
• Male
• Membrane Glycoproteins (immunology)
• Middle Aged
• Nuclear Pore Complex Proteins
• Nuclear Proteins (immunology)
• Peptide Fragments (immunology)
• Probability
• Retrospective Studies
• Survival Analysis
• Treatment Outcome
• Ursodeoxycholic Acid (therapeutic use)