First military use of activated Factor VII in an APC-III pelvic fracture.

Abstract

A male soldier in shock with an APC-III pelvic fracture was flown to an Air Assault Surgical Group (AASG) of 16 Close Support Medical Regiment at Al Amarah in Iraq. A pelvic external fixator was applied and his condition stabilized. Ultrasound scanning (FAST) showed an absent bladder, and a spreading retroperitoneal haematoma combined with intra-abdominal, free blood. Unfortunately he continued to bleed and required transfusion with the unit's entire stock of type-specific blood. At emergency laparotomy, uncontrollable pelvic bleeding was encountered and the abdominal aorta required clamping above the iliac bifurcation. Branches of the right internal iliac artery were the source and this was ligated. Some bleeding continued post-operatively: administration of activated Factor VII was associated with a marked reduction in the oozing from his fixator pin-sites and an improvement in his pH from 7.1 to 7.3. In total, 25 units of blood were transfused, 8 of which were fresh whole blood donated by individual members of the AASG. The patient survived, returned to the UK, had his injuries reconstructed, and is currently undergoing rehabilitation. This case illustrates the benefits of forward resuscitation surgery in wartime and the need for a multidisciplinary approach to trauma care.

• Authors: D J Williams, G O R Thomas, S Pambakian, P J Parker
• Journal: Injury (Injury) Vol. 36 Issue 3 Pg. 395-9 (Mar 2005) ISSN: 0020-1383 [Print] Netherlands
• PMID: 15710156 (Publication Type: Case Reports, Journal Article)

Chemical References

• Factor VIIa

Topics

• Factor VIIa (therapeutic use)
• Femoral Fractures (surgery, therapy)
• Fracture Fixation (methods)
• Fractures, Bone (surgery, therapy)
• Hematoma (drug therapy, etiology)
• Humans
• Male
• Military Personnel
• Multiple Trauma (surgery)
• Pelvic Bones (diagnostic imaging, injuries)
• Radiography
• Retroperitoneal Space
• Sacroiliac Joint (diagnostic imaging, injuries)
• Treatment Outcome