HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[A study on risk of malignant neoplasm and environmental exposure to crocidolite].

AbstractOBJECTIVE:
To explore the risk of developing malignant neoplasm in a cohort with the history of environmental exposure to crocidolite asbestos.
METHODS:
A retrospective cohort and follow-up study covering 15 years (1987 --> 1995 --> 2001) was carrid out in a small town in Yunnan province. The cohort comprised 6254 local inhabitants. The deaths from and the RR of asbestos-related malignant neoplasms were studied.
RESULTS:
There were 186 deaths from neoplasms in the observation group, the mortality being 2160.5 per 10(6) person-years (RR=1.293, 95%CI: 1.032-1.618), 20 of those deaths were caused by mesothelioma, with a crude mortality of 232.3 per 10(6) person-years (RR=17.929; 95%CI: 2.406-133.592). The mortalities for men and women were 267.5 and 186.7 per 10(6) person-years respectively. The crude mortality from lung cancer (56 deaths) was 650.5 per 10(6) person-years,there is no significance between the two groups (RR=1.434; 95%CI: 0.968-2.486). The difference in mortality from gastrointestinal cancer between the two groups is not significant, whereas the risk of man intestinal cancer in the observation is significant (RR=3.71; 95%CI: 1.077-13.270).
CONCLUSION:
The risk of developing mesothelioma is significantly increased in the population with environmental exposure to crocidolite. The risk of man intestinal cancer in the town awaits additional studies.
AuthorsSu-qiong Luo, Shi-hui Mu, Jin-tao Wang, Yi Zhang, Qi-bang Wen, Shan-pu Cai
JournalSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition (Sichuan Da Xue Xue Bao Yi Xue Ban) Vol. 36 Issue 1 Pg. 105-7 (Jan 2005) ISSN: 1672-173X [Print] China
PMID15702795 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Asbestos, Crocidolite
Topics
  • Adult
  • Aged
  • Asbestos, Crocidolite (adverse effects)
  • China (epidemiology)
  • Cohort Studies
  • Environmental Exposure (adverse effects)
  • Female
  • Follow-Up Studies
  • Humans
  • Lung Neoplasms (epidemiology, etiology, mortality)
  • Male
  • Mesothelioma (epidemiology, etiology, mortality)
  • Middle Aged
  • Pleural Neoplasms (epidemiology, etiology, mortality)
  • Retrospective Studies
  • Risk Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: