Abstract | BACKGROUND: PROCEDURE: We treated a 14-year-old female who had multiple osteolytic lesions and hypercalcemia at initial onset of ALL. In this case we examined some humoral factors, which are known to associate with hypercalcemia in malignancies. RESULTS: CONCLUSIONS: The present case suggests that blast-producing PTHrP might be associated with multiple osteolytic lesions and hypercalcemia. PTHrP expressed in the lymphoblasts may, in itself, confer a survival advantage to lymphoblasts and contribute to the refractory nature of the disease.
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Authors | Hidemi Shimonodan, Jun Nagayama, Yoshihisa Nagatoshi, Michiki Hatanaka, Akiko Takada, Haruo Iguchi, Yoshinao Oda, Jun Okamura |
Journal | Pediatric blood & cancer
(Pediatr Blood Cancer)
Vol. 45
Issue 3
Pg. 333-9
(Sep 2005)
ISSN: 1545-5009 [Print] United States |
PMID | 15700250
(Publication Type: Case Reports, Journal Article, Review)
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Copyright | (c) 2004 Wiley-Liss, Inc. |
Chemical References |
- Parathyroid Hormone-Related Protein
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Topics |
- Adolescent
- Fatal Outcome
- Female
- Humans
- Hypercalcemia
(blood, etiology)
- Osteolysis
(blood, etiology)
- Parathyroid Hormone-Related Protein
(blood)
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(blood, complications)
- Recurrence
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