Abstract | BACKGROUND: METHODS: RESULTS: Forty-six patients received standard therapy, and 40 patients received standard therapy plus plasmapheresis. The mean follow-up was 136 weeks. Six patients (13 percent) in the standard-therapy group and eight patients (20 percent) in the plasmapheresis group died. Renal failure developed in 8 patients (17 percent) in the standard-therapy group, as compared with 10 (25 percent) in the plasmapheresis group. Thirty patients (35 percent) reached stopping points--14 (30 percent) in the standard-therapy group and 16 (40 percent) in the plasmapheresis group. A similar number of patients in each group had a decrease in both the serum creatinine concentration and urinary protein excretion to approximately normal values. Patients treated with plasmapheresis had a significantly more rapid reduction of serum concentrations of antibodies against double-stranded DNA and cryoglobulins. CONCLUSIONS:
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Authors | E J Lewis, L G Hunsicker, S P Lan, R D Rohde, J M Lachin |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 326
Issue 21
Pg. 1373-9
(May 21 1992)
ISSN: 0028-4793 [Print] United States |
PMID | 1569973
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Autoantibodies
- Cryoglobulins
- Cyclophosphamide
- DNA
- Creatinine
- Prednisone
|
Topics |
- Adult
- Autoantibodies
(analysis)
- Combined Modality Therapy
- Creatinine
(blood)
- Cryoglobulins
(immunology)
- Cyclophosphamide
(administration & dosage)
- DNA
(immunology)
- Drug Therapy, Combination
- Female
- Humans
- Lupus Nephritis
(therapy)
- Male
- Plasmapheresis
- Prednisone
(administration & dosage)
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