| Abstract | Docetaxel, a semisynthetic taxane initially developed for the treatment of breast cancer, has a high degree of activity in lung cancer. Although the mechanisms of action of the taxanes docetaxel and paclitaxel are identical, docetaxel has almost a twofold higher binding affinity for the target site, beta tubulin. In clinical trials, individuals previously treated with paclitaxel benefited from docetaxel. Docetaxel is the standard of care in second-line therapy of advanced non-small-cell lung cancer (NSCLC) and is effective, alone and in combination, in first-line treatment of advanced NSCLC. The standard in first-line therapy of metastatic NSCLC is a platinum doublet with one of the third-generation chemotherapy agents, docetaxel, paclitaxel, gemcitabine, or vinorelbine. Each of these doublets offers similar therapeutic benefit. In a phase-III study comparing docetaxel-cisplatin and docetaxel-carboplatin with vinorelbine-cisplatin, patients treated in the two docetaxel arms had consistently improved global QoL compared to patients treated with the vinorelbine-cisplatin doublet. This landmark study led to Food and Drug Administration (FDA) approval of cisplatin-docetaxel for the treatment of advanced NSCLC. Non-platinum doublets such as docetaxel-gemcitabine have also demonstrated efficacy and safety. Docetaxel has undergone extensive evaluation and is the only agent approved for use in both first- and second-line therapy of advanced NSCLC. |
| Authors | Chandra P Belani, John Eckardt
(Affiliation: University of Pittsburgh School of Medicine, and Lung and Thoracic Cancer Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA. Belanicp at upmc.edu)
|
| Journal | Lung cancer (Amsterdam, Netherlands)
(Lung Cancer)
Vol. 46 Suppl 2
Pg. S3-11
(Dec 2004)
ISSN: 0169-5002 Ireland |
| PMID | 15698529
(Publication Type: Journal Article, Review)
|
| Chemical References |
- Antineoplastic Agents, Phytogenic
- Taxoids
- gemcitabine
- docetaxel
- Cisplatin
- Paclitaxel
- Carboplatin
- vinorelbine
- Vinblastine
- Deoxycytidine
|
| Topics |
- Antineoplastic Agents, Phytogenic
(therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Carboplatin
(administration & dosage)
- Carcinoma, Non-Small-Cell Lung
(drug therapy)
- Cisplatin
(administration & dosage)
- Clinical Trials as Topic
- Deoxycytidine
(administration & dosage, analogs & derivatives)
- Humans
- Lung Neoplasms
(drug therapy)
- Paclitaxel
(administration & dosage)
- Taxoids
(therapeutic use)
- Vinblastine
(administration & dosage, analogs & derivatives)
|
