Abstract | BACKGROUND: METHODS: Hepatic tissue LRP mRNA abundance [reverse transcription-polymerase chain reaction (RT-PCR)] and protein abundance (Western blot analysis) were determined in rats 8 weeks after 5/6 nephrectomy (CRF group) or sham operation (control group). RESULTS: The CRF group exhibited hypertension, diminished creatinine clearance, increased plasma triglyceride concentration, and elevated total cholesterol-to- HDL cholesterol concentration ratio compared to the corresponding values found in the control group. This was associated with a significant down-regulation of hepatic LRP mRNA expression and immunodetectable LRP protein. CONCLUSION: CRF results in down-regulation of hepatic LRP. This abnormality can, at least in part, account for the previously documented elevation of plasma concentration and depressed clearance of chylomicron remnants and IDL in CRF.
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Authors | Choong Kim, Nosratola D Vaziri |
Journal | Kidney international
(Kidney Int)
Vol. 67
Issue 3
Pg. 1028-32
(Mar 2005)
ISSN: 0085-2538 [Print] United States |
PMID | 15698441
(Publication Type: Journal Article)
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Chemical References |
- LDL-Receptor Related Proteins
- Lipoproteins
- lipoprotein cholesterol
- Cholesterol
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Topics |
- Animals
- Cholesterol
(genetics)
- Down-Regulation
- Gene Expression Regulation
- Kidney Failure, Chronic
(metabolism)
- LDL-Receptor Related Proteins
(genetics)
- Lipoproteins
(genetics)
- Liver
(metabolism)
- Male
- Rats
- Rats, Sprague-Dawley
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