No associations between Parkinson's disease and polymorphisms of the quinone oxidoreductase (NQO1, NQO2) genes.

Abstract

Reactive oxygen species derived from dopamine metabolism can induce oxidative stress and thus may contribute to Parkinson's disease (PD) pathogenesis. The quinone oxidoreductases, nicotinamide adenine dinucleotide (phosphate) (NAD[P]H): quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside (NRH): quinone oxidoreductase 2 (NQO2) detoxify quinones and quinonoid compounds. We investigated associations of genetic polymorphisms of NQO1 (C609T) and NQO2 (I/D, 29 base pairs) with PD in a population-based case-control study of 190 idiopathic PD cases and 305 unrelated controls matched on age and sex. No associations were detected for either gene variant or for any allele combinations.

• Authors: Starlyn Okada, Federico M Farin, Patricia Stapleton, Hanna Viernes, Sean D Quigley, Karen M Powers, Terri Smith-Weller, Gary M Franklin, W T Longstreth, Phillip D Swanson, Harvey Checkoway
• Journal: Neuroscience letters (Neurosci Lett) Vol. 375 Issue 3 Pg. 178-80 (Mar 03 2005) ISSN: 0304-3940 [Print] Ireland
• PMID: 15694256 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• NAD(P)H Dehydrogenase (Quinone)
• NQO1 protein, human
• NRH - quinone oxidoreductase2
• Quinone Reductases

Topics

• Aged
• Alleles
• Case-Control Studies
• Confidence Intervals
• Female
• Genotype
• Humans
• Male
• Molecular Sequence Data
• NAD(P)H Dehydrogenase (Quinone) (genetics)
• Odds Ratio
• Parkinson Disease (genetics)
• Polymorphism, Genetic
• Quinone Reductases (genetics)