alpha-Internexin immunoreactivity reflects variable neuronal vulnerability in Alzheimer's disease and supports the role of the beta-amyloid plaques in inducing neuronal injury.

Abstract	This study investigated the role of alpha-internexin in the neuronal alterations associated with beta-amyloid plaque formation in Alzheimer's disease (AD). Cortical neurons could be defined by their variable content of neurofilament (NF) triplet and alpha-internexin proteins, with a distinct population of supragranular pyramidal cells containing alpha-internexin alone. Both NF triplet and alpha-internexin were localized to reactive axonal structures in physically damaged neurons in experimental trauma models. Similarly, NF triplet and alpha-internexin immunoreactive neurites were localized to plaques densely packed with beta-amyloid fibrils in preclinical AD cases, indicating that certain plaques may cause structural injury or impediment of local axonal transport. However, alpha-internexin, and not NF triplet, ring-like reactive neurites were present in end-stage AD cases, indicating the relatively late involvement of neurons that selectively contain alpha-internexin. These results implicate the expression of specific intermediate filament proteins in a distinct hierarchy of differential neuronal vulnerability to AD.
Authors	Tracey C Dickson, Jyoti A Chuckowree, Meng Inn Chuah, Adrian K West, James C Vickers
Journal	Neurobiology of disease (Neurobiol Dis) Vol. 18 Issue 2 Pg. 286-95 (Mar 2005) ISSN: 0969-9961 [Print] United States
PMID	15686957 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Amyloid beta-Peptides Carrier Proteins Intermediate Filament Proteins Neurofilament Proteins alpha-internexin
Topics	Aged Aged, 80 and over Alzheimer Disease (metabolism, pathology) Amyloid beta-Peptides (metabolism) Animals Brain Injuries (metabolism, pathology) Carrier Proteins (metabolism) Causality Cerebral Cortex (metabolism, pathology) Disease Models, Animal Female Humans Immunohistochemistry Intermediate Filament Proteins Male Middle Aged Nerve Degeneration (metabolism, pathology) Neurites (metabolism, pathology) Neurofilament Proteins (metabolism) Neurons (metabolism, pathology) Plaque, Amyloid (metabolism, pathology) Pyramidal Cells (metabolism, pathology) Rats Rats, Wistar

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