Abstract |
We previously reported that the concentration of 5-hydroxytryptamine (5-HT) in the brainstem of cisplatin-administered ferrets is significantly increased as compared with that of control animals. In an attempt to clarify the mechanisms of emesis induced by cytotoxic drugs, we measured kaolin ingestion ( pica) and the tissue concentrations of 5-HT, norepinephrine (NE) and dopamine in various brain regions of rats after cisplatin administration. 5-HT concentrations in the hippocampus, the medulla oblongata and the hypothalamus significantly increased 72 hours after a single dose administration of cisplatin (5 mg/kg, i.p.) compared with those of control rats. NE concentration in the hippocampus significantly increased simultaneously with kaolin ingestion in cisplatin-treated rats. These results suggest that higher brain regions such as the hippocampus and the hypothalamus are involved in cisplatin-induced emesis.
|
Authors | Yanxia Liu, Naoya Hamaue, Toru Endo, Masahiko Hirafuji, Masaru Minami |
Journal | Research communications in molecular pathology and pharmacology
(Res Commun Mol Pathol Pharmacol)
Vol. 113-114
Pg. 97-113
( 2003)
ISSN: 1078-0297 [Print] United States |
PMID | 15686111
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antineoplastic Agents
- Sympathomimetics
- 3,4-Dihydroxyphenylacetic Acid
- Kaolin
- Serotonin
- Hydroxyindoleacetic Acid
- Cisplatin
- Dopamine
- Norepinephrine
|
Topics |
- 3,4-Dihydroxyphenylacetic Acid
(metabolism)
- Animals
- Antineoplastic Agents
(toxicity)
- Brain
(drug effects, metabolism)
- Cisplatin
(toxicity)
- Dopamine
(metabolism)
- Hydroxyindoleacetic Acid
(metabolism)
- Kaolin
- Male
- Norepinephrine
(metabolism)
- Pica
(chemically induced)
- Rats
- Rats, Wistar
- Serotonin
(metabolism)
- Sympathomimetics
(metabolism)
- Vomiting
(chemically induced)
|