Anti-inflammatory strategies in hypertension: focus on COX-1 and COX-2.

Abstract

An increasing body of evidence suggests that elevated levels of blood pressure may induce a proinflammatory response. Indeed, both C-reactive protein and blood pressure are independent determinants of cardiovascular risk, and, in combination, each parameter has additional predictive value. Hence, strategies targeted to lower blood pressure and reduce vascular inflammation may potentially provide clinical benefit. In this review, we discuss the role of chronic low-grade inflammation in the context of cardiovascular disease with a focus on roles of cyclooxygenase-1 and -2 in potential anti-inflammatory treatment strategies.

• Authors: Matthias Hermann, Frank Enseleit, Frank T Ruschitzka
• Journal: Current hypertension reports (Curr Hypertens Rep) Vol. 7 Issue 1 Pg. 52-60 (Feb 2005) ISSN: 1522-6417 [Print] United States
• PMID: 15683587 (Publication Type: Journal Article, Review)

Chemical References

• Cyclooxygenase Inhibitors
• Nitric Oxide

Topics

• Cardiovascular Diseases (prevention & control)
• Cyclooxygenase Inhibitors (pharmacology)
• Endothelium, Vascular (physiopathology)
• Humans
• Hypertension (drug therapy, physiopathology)
• Inflammation (drug therapy, physiopathology)
• Nitric Oxide (physiology)