Infection is the leading cause of morbidity that occurs after
breast implantation and complicates 2.0-2.5% of interventions in most case series. Two-thirds of
infections develop within the acute post-operative period, whereas some
infections may develop years or even decades after surgery.
Infection rates are higher after
breast reconstruction and subsequent implantation than after breast augmentation. Risk factors for
infection associated with
breast implantation have not been carefully assessed in prospective studies with long-term follow-up. Surgical technique and the patient's underlying condition are the most important determinants. In particular,
breast reconstruction after
mastectomy and
radiotherapy for
cancer is associated with a higher risk for
infection. The origin of
infection in women with implants remains difficult to determine, but potential sources include a contaminated implant, contaminated saline, the surgery itself or the surgical environment, the patient's skin or mammary ducts, or, as suggested by many reports, seeding of the implant from remote
infection sites. Late
infection usually results from secondary bacteraemia or an invasive procedure at a location other than breasts. Diagnostic and management strategies are proposed and the value of peri-operative surgical prophylaxis is revisited. The current hypothesis of the possible role of low-grade or
subclinical infection in the origin of capsular
contracture is also reviewed.