The efficacy and safety of transnasal butorphanol for postoperative pain control following lower laparoscopic surgery.

The aim of the study was to evaluate the efficacy and safety of transnasal butorphanol for postoperative analgesia in adult female patients undergoing lower laparoscopic surgery.
Fifty-six women undergoing lower laparoscopic surgery under general anesthesia were enrolled in the study. They were randomly divided into 2 groups (n = 28 each). Postoperatively, group 1 received transnasal butorphanol 2 mg, whereas group 2 received transnasal placebo. During a 6-h post-treatment period, we collected the following data: scores of visual analogue pain scale, demand and delivery of patient-controlled analgesia (PCA) morphine, vital signs, nausea, vomiting, and somnolence.
Transnasal butorphanol clearly proved to have analgesic effect when compared with placebo as revealed by diminishment of visual analogue scale scores at 30 min (P = 0.043), less consumption of PCA morphine at 30-60 min (P = 0.002), and less demand of PCA morphine at 30-60 min (P = 0.001) and 60-180 min (P = 0.031). All patients displayed stable vital signs. The side effects between groups were not significantly different.
In contrast with placebo transnasal butorphanol was effective in the treatment of postoperative pain in female patients undergoing lower laparoscopic surgery. It had minimum side effects.
AuthorsChin-Chen Chu, Jen-Yin Chen, Cheng-Shih Chen, Jann-Inn Tzeng, Chih-Hsin Tzeng, Pei-Shan Chiang, Jhi-Joung Wang
JournalActa anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists (Acta Anaesthesiol Taiwan) Vol. 42 Issue 4 Pg. 203-7 (Dec 2004) ISSN: 1875-4597 [Print] China (Republic : 1949- )
PMID15679129 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Analgesics, Opioid
  • Butorphanol
  • Administration, Intranasal
  • Adult
  • Analgesics, Opioid (administration & dosage)
  • Butorphanol (administration & dosage, adverse effects)
  • Female
  • Humans
  • Laparoscopy
  • Middle Aged
  • Pain, Postoperative (drug therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: