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The efficacy and safety of transnasal butorphanol for postoperative pain control following lower laparoscopic surgery.

AbstractBACKGROUND:
The aim of the study was to evaluate the efficacy and safety of transnasal butorphanol for postoperative analgesia in adult female patients undergoing lower laparoscopic surgery.
METHODS:
Fifty-six women undergoing lower laparoscopic surgery under general anesthesia were enrolled in the study. They were randomly divided into 2 groups (n = 28 each). Postoperatively, group 1 received transnasal butorphanol 2 mg, whereas group 2 received transnasal placebo. During a 6-h post-treatment period, we collected the following data: scores of visual analogue pain scale, demand and delivery of patient-controlled analgesia (PCA) morphine, vital signs, nausea, vomiting, and somnolence.
RESULTS:
Transnasal butorphanol clearly proved to have analgesic effect when compared with placebo as revealed by diminishment of visual analogue scale scores at 30 min (P = 0.043), less consumption of PCA morphine at 30-60 min (P = 0.002), and less demand of PCA morphine at 30-60 min (P = 0.001) and 60-180 min (P = 0.031). All patients displayed stable vital signs. The side effects between groups were not significantly different.
CONCLUSIONS:
In contrast with placebo transnasal butorphanol was effective in the treatment of postoperative pain in female patients undergoing lower laparoscopic surgery. It had minimum side effects.
AuthorsChin-Chen Chu, Jen-Yin Chen, Cheng-Shih Chen, Jann-Inn Tzeng, Chih-Hsin Tzeng, Pei-Shan Chiang, Jhi-Joung Wang
JournalActa anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists (Acta Anaesthesiol Taiwan) Vol. 42 Issue 4 Pg. 203-7 (Dec 2004) ISSN: 1875-4597 [Print] China (Republic : 1949- )
PMID15679129 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Analgesics, Opioid
  • Butorphanol
Topics
  • Administration, Intranasal
  • Adult
  • Analgesics, Opioid (administration & dosage)
  • Butorphanol (administration & dosage, adverse effects)
  • Female
  • Humans
  • Laparoscopy
  • Middle Aged
  • Pain, Postoperative (drug therapy)

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