Abstract | OBJECTIVE: Microthrombus formation appears to be one of the major detrimental factors in lung transplantation from non-heart-beating donors. The purpose of this study was to evaluate the effects of postmortem heparinization by closed-chest cardiac massage in a canine model of left single-lung allotransplantation from non-heart-beating donors. METHODS: RESULTS: Both groups 2 and 3 had significantly better gas exchange and lower pulmonary vascular resistance than group 1. Changes in thrombin-antithrombin III complex concentration during the warm ischemia indicated that postmortem heparinization suppressed clotting activation in the donor. CONCLUSIONS:
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Authors | Hidetoshi Inokawa, Hiroshi Date, Mikio Okazaki, Daisuke Okutani, Keiju Aokage, Itaru Nagahiro, Motoi Aoe, Yoshifumi Sano, Nobuyoshi Shimizu |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 129
Issue 2
Pg. 429-34
(Feb 2005)
ISSN: 0022-5223 [Print] United States |
PMID | 15678056
(Publication Type: Comparative Study, Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticoagulants
- Biomarkers
- antithrombin III-protease complex
- Antithrombin III
- Heparin
- Peptide Hydrolases
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Topics |
- Animals
- Anticoagulants
(pharmacology)
- Antithrombin III
(drug effects, metabolism)
- Biomarkers
(blood)
- Disease Models, Animal
- Dogs
- Heart
(drug effects, physiopathology)
- Heart Arrest, Induced
- Heart Massage
- Heparin
(pharmacology)
- Lung
(drug effects, metabolism, pathology)
- Lung Transplantation
- Models, Cardiovascular
- Peptide Hydrolases
(drug effects, metabolism)
- Postmortem Changes
- Respiratory Function Tests
- Vascular Resistance
(drug effects, physiology)
- Whole Blood Coagulation Time
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