Efficacy of intravenous immunoglobulin in chronic idiopathic pericarditis: report of four cases.

Human intravenous immunoglobulins (hIVIgs) are used in two broad categories of diseases: immunodeficiency and autoimmunity. Among the immune-mediated diseases hIVIgs are of benefit in idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, and dermatomyositis. Chronic idiopathic pericarditis (CIP) is a chronic disease of unknown origin characterized by recurrent episodes of pericardial inflammation. The cause of the recurrence is unknown, although in some cases it may be traced to a viral infection and to the presence of antimyocardial antibodies. Since a viral infection can induce an autoimmune process through a mechanism of molecular mimicry, and since the optimal therapy for prevention of the recurrences has not been established, we reasoned that treatment with hIVIgs could be beneficial in our patients unresponsive to previous immunosuppressive therapies. We describe four patients affected by CIP treated with monthly high-dose hIVIgs (0.4 g/kg daily for 5 consecutive days) for five times followed by administration every 2 months. Three of the four patients could permanently discontinue steroid therapy and are still in remission after years of follow-up. Our experience suggests that hIVIgs therapy may be a useful and safe treatment for CIP in steroid-dependent patients.
AuthorsD Peterlana, A Puccetti, S Simeoni, E Tinazzi, R Corrocher, C Lunardi
JournalClinical rheumatology (Clin Rheumatol) Vol. 24 Issue 1 Pg. 18-21 (Feb 2005) ISSN: 0770-3198 [Print] Belgium
PMID15674654 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Immunoglobulins, Intravenous
  • Adult
  • Child
  • Chronic Disease
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Echocardiography
  • Follow-Up Studies
  • Humans
  • Immunoglobulins, Intravenous (administration & dosage)
  • Male
  • Pericarditis (drug therapy, ultrasonography)
  • Recurrence
  • Remission Induction (methods)
  • Retrospective Studies
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: