Long-term efficacy of soy-based meal replacements vs an individualized diet plan in obese type II DM patients: relative effects on weight loss, metabolic parameters, and C-reactive protein.

Abstract

BACKGROUND:

Achieving significant weight loss and glycemic control in diabetic patients remains a challenging task.

OBJECTIVE:

This study compared the effects of a soy-based meal replacement (MR) plan vs an individualized diet plan (IDP; as recommended by the American Diabetes Association) on weight loss and metabolic profile.

DESIGN/SUBJECTS:

A total of 104 subjects were randomized prospectively to the two treatments for a total of 12 months.

RESULTS:

In all, 77 of the 104 subjects completed the study. Percentage weight loss in MR group (4.57+/-0.81%) was significantly greater (P<0.05) than in IDP group (2.25+/-0.72%). Fasting plasma glucose was significantly reduced in MR group (126.4+/-4.9 mg/dl) compared with IDP group (152.5+/-6.6 mg/dl, P<0.0001) at 6 months but not at 12 months. Controlling for baseline levels, hemoglobin Alc level improved by 0.49+/-0.22% for those receiving MR when compared to IDP group (P<0.05). A greater number of subjects in MR group reduced their use of sulfonylureas (P<0.0001) and metformin (P<0.05) as compared to IDP group. High-sensitivity C-reactive protein (hs-CRP) decreased -26.3% (P = 0.019) in MR group compared to -7.06% (P = 0.338) in IDP group at 6 months. Similar changes were observed at 12 months with MR groups, with hs-CRP decreasing by -25.0% (P = 0.019) compared to -18.7% (P = 0.179) in IDP group.

CONCLUSION:

This study demonstrates that MR is a viable strategy for weight reduction in diabetic patients, resulting in beneficial changes in measures of glycemic control and reduction of medications.

• Authors: Z Li, K Hong, P Saltsman, S DeShields, M Bellman, G Thames, Y Liu, H-J Wang, R Elashoff, D Heber
• Journal: European journal of clinical nutrition (Eur J Clin Nutr) Vol. 59 Issue 3 Pg. 411-8 (Mar 2005) ISSN: 0954-3007 [Print] England
• PMID: 15674301 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Glycated Hemoglobin A
• Lipids
• C-Reactive Protein

Topics

• Blood Glucose (metabolism)
• Body Mass Index
• C-Reactive Protein (metabolism)
• Diabetes Mellitus, Type 2 (blood, diet therapy)
• Female
• Food, Formulated
• Glycated Hemoglobin (metabolism)
• Humans
• Lipids (blood)
• Longitudinal Studies
• Male
• Middle Aged
• Obesity (blood, diet therapy)
• Prospective Studies
• Soy Foods
• Treatment Outcome
• Weight Loss (physiology)