Anti-ribosomal-P antibodies in a Sjögren syndrome patient associated with lupus erythematosus.

Abstract

We describe a 36-year-old woman who had Sjögren syndrome with anti-ribosomal P antibodies and who developed erythema on her back and arms. The histological specimen showed lymphocytic infiltration around the sweat and salivary glands. Her serum reacted with ribosomal-P0 protein in immunoblotting with HeLa cell extract and P0 recombinant protein. Although autoantibodies to ribosomal-P proteins appear mainly in patients with systemic lupus erythematosus (SLE), a diagnosis of SLE in this patient could not be supported.

• Authors: Yoshinao Muro, Yasushi Tomita
• Journal: The Journal of dermatology (J Dermatol) Vol. 31 Issue 10 Pg. 811-4 (Oct 2004) ISSN: 0385-2407 [Print] England
• PMID: 15672709 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• Biomarkers
• L12E protein, Trypanosoma cruzi
• Protozoan Proteins
• Ribosomal Proteins
• Prednisolone

Topics

• Adult
• Autoantibodies (immunology)
• Biomarkers (analysis)
• Biopsy, Needle
• Female
• Fluorescent Antibody Technique, Indirect
• Follow-Up Studies
• Humans
• Immunohistochemistry
• Lupus Erythematosus, Systemic (complications, drug therapy, immunology, pathology)
• Prednisolone (therapeutic use)
• Protozoan Proteins
• Ribosomal Proteins (immunology)
• Risk Assessment
• Severity of Illness Index
• Sjogren's Syndrome (complications, drug therapy, immunology, pathology)
• Treatment Outcome