In vitro antiproliferative effects of tricyclic psychopharmaceutical agents and synergism with some resistance modifiers.

Abstract

Some of the phenothiazines and dibenz[b,f]azepines exert an antiproliferative effect on HEp-2 and rat prolactinoma cells. The same compounds also have effects on different membrane-bound biochemical events, such as H2O2 formation and the peroxide-generated chemiluminescence of polymorphonuclear leukocytes. The superoxide dismutase inhibition by 7,8-dioxochlorpromazine and 6,9-dioxochlorpromazine have some relation to the growth inhibitory action on the growth of HEP-2 and prolactinoma cells in vitro. The antiproliferative effects of phenothiazines were synergized with resistance modifiers like verapamil, omeprazole and tubulozole-C, due to increased drug-influx or decreased drug-efflux and due to possible action on the cytoskeleton.

• Authors: J Molnar, B Tarodi, M Galfi, B Matkovics, N Motohashi
• Journal: Anticancer research (Anticancer Res) 1992 Jan-Feb Vol. 12 Issue 1 Pg. 273-80 ISSN: 0250-7005 [Print] Greece
• PMID: 1567177 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Dioxolanes
• Phenothiazines
• Psychotropic Drugs
• tubulazole
• Verapamil
• Superoxide Dismutase

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Dioxolanes (pharmacology)
• Drug Resistance
• Drug Synergism
• Humans
• Neutrophils (drug effects, metabolism)
• Phenothiazines (pharmacology)
• Psychotropic Drugs (pharmacology)
• Rats
• Structure-Activity Relationship
• Superoxide Dismutase (antagonists & inhibitors)
• Tumor Cells, Cultured (drug effects)
• Verapamil (pharmacology)