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Polygynax in the treatment of fungal and non specific vaginitis.

AbstractBACKGROUND:
Polygynax is a product commercialized in the form of vaginal capsule, associating bactericidal antibiotics: Neomycin, Polymyxin B and Nystatin--an antifungal agent which is fungicidal and fungistatic in vitro and in vivo.
OBJECTIVE:
The objectives of the study were to analyze the clinical and bacteriological efficacy of Polygynax in the treatment of bacterial vaginitis with one or more germs (mixed vaginitis) and Candida infections, and to investigate the correlation between the results of the initial clinical examination and bacteriological studies.
MATERIAL AND METHODS:
The study covered 88 patients diagnosed with mixed vaginitis during initial screening of vaginal flora (direct Gram stains and standard microbiology laboratory methods for cultivation of vagina/ cervix smears with antibiotic susceptibility testing). The patients were treated with Polygynax, applied in form of vaginal capsules (during 12 days, application before retiring). After at least 30 days following last day of therapy, the same diagnostic swabs were repeated. In this period, averaging 38.4 days, sexual abstinence was recommended.
RESULTS:
The results showed that total clearance of present germs was found in 83/88 patients (94.3% of the cases), according to the repeated cervico- vaginal smears.
CONCLUSION:
Polygynax is a treatment of preference against fungal infections, with added advantage of having wide antibacterial spectrum.
AuthorsDimitrov Goran, Antovska Vesna, Stefanija Adela, Trajkovska-Kiurcik Biljana, Milenkova Snezana
JournalAkusherstvo i ginekologii͡a (Akush Ginekol (Sofiia)) Vol. 43 Issue 6 Pg. 23-6 ( 2004) ISSN: 0324-0959 [Print] Bulgaria
PMID15669649 (Publication Type: Journal Article)
Chemical References
  • Arsenicals
  • Drug Combinations
  • Polymyxins
  • Nystatin
  • Neomycin
  • acetarsol, dimethicone, neomycin, nystatin, polymyxin drug combination
Topics
  • Arsenicals (administration & dosage, therapeutic use)
  • Candidiasis, Vulvovaginal (drug therapy, microbiology)
  • Drug Combinations
  • Female
  • Humans
  • Neomycin (administration & dosage, therapeutic use)
  • Nystatin (administration & dosage, therapeutic use)
  • Polymyxins (administration & dosage, therapeutic use)
  • Treatment Outcome
  • Vaginal Smears
  • Vaginosis, Bacterial (drug therapy, microbiology)

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