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Treatment of atrophic vaginitis with topical conjugated equine estrogens in postmenopausal Asian women.

AbstractOBJECTIVE:
We investigated the effects of 2 months of treatment with topical estrogens on atrophic vaginitis and gynecological health in Asian women.
STUDY DESIGN:
Multicenter, open-label trial of 150 postmenopausal women age <70 years with atrophic vaginitis. Women applied conjugated equine estrogens (CEE) vaginal cream (0.625 mg/g) once daily on days 1-21 of two 28-day cycles. Changes in the vaginal maturation index (VMI) from baseline to days 21 (month 1) and 49 (month 2) were the primary outcome. Physiological changes were assessed by the Genital Health Clinical Examination (GHCE).
RESULTS:
The VMI was significantly improved (p < 0.001) from baseline at each assessment period. The significant improvement in GHCE from baseline after 1 month (p < 0.001) was maintained at 2 months.
CONCLUSIONS:
Vaginal treatment with CEE cream for 21 days of two consecutive 28-day cycles resulted in beneficial changes in the vaginal tissues and induced an overall genital health pattern more characteristic of the premenopausal state.
AuthorsN Raymundo, B Yu-cheng, H Zi-yan, C Huey Lai, K Leung, R Subramaniam, C Bin-rong, Y S Ling, N Nasri, N Calimon
JournalClimacteric : the journal of the International Menopause Society (Climacteric) Vol. 7 Issue 3 Pg. 312-8 (Sep 2004) ISSN: 1369-7137 [Print] England
PMID15669556 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Estrogens, Conjugated (USP)
Topics
  • Administration, Cutaneous
  • Adult
  • Aged
  • Asian People
  • China
  • Estrogen Replacement Therapy
  • Estrogens, Conjugated (USP) (administration & dosage)
  • Female
  • Hong Kong
  • Humans
  • Malaysia
  • Middle Aged
  • Philippines
  • Postmenopause
  • Severity of Illness Index
  • Singapore
  • Taiwan
  • Treatment Outcome
  • Vaginitis (drug therapy, genetics, pathology)
  • Women's Health

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