Abstract |
Primary synovial sarcoma outside its classical presentation in para-articular soft tissue of young patients is rare but regularly reported. One of the rarest primary locations is the lung. We describe a 73-year-old female patient who presented with a solitary malignant bone tumor 8 years after the resection of a lung neoplasm. The bone tumor was classified as an osteosarcoma and the lung tumor as an atypical carcinoid tumor at their first respective diagnostic work-ups. The resection of the affected humerus with allograft and endoprosthesis implantation followed. Reevaluation of the tumor samples at the time of the local recurrence of the bone tumor 6 years following the initial symptoms of the bone tumor lead to the reclassification of both specimens as synovial sarcomas. Both neoplasms contained the SYT-SSX1 type of the diagnostic translocation t(X;18) as detected by the reverse-transcription polymerase chain reaction analysis. The patient died 14 years after the resection of the primary synovial sarcoma of the lung and 6 years following the occurrence of the bone metastasis. This prolonged clinical course is uncommon for the SYT-SSX1 translocation, which, in other locations, is usually associated with an unfavorable prognosis.
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Authors | B Bode-Lesniewska, J Hodler, A von Hochstetter, L Guillou, U Exner, R Caduff |
Journal | Virchows Archiv : an international journal of pathology
(Virchows Arch)
Vol. 446
Issue 3
Pg. 310-5
(Mar 2005)
ISSN: 0945-6317 [Print] Germany |
PMID | 15668803
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Oncogene Proteins, Fusion
- SYT-SSX fusion protein
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Topics |
- Aged
- Bone Neoplasms
(genetics, pathology, secondary)
- Diagnosis, Differential
- Diagnostic Errors
- Female
- Humans
- Immunohistochemistry
- Lung Neoplasms
(genetics, pathology)
- Oncogene Proteins, Fusion
- Osteosarcoma
(pathology)
- Reverse Transcriptase Polymerase Chain Reaction
- Sarcoma, Synovial
(genetics, pathology, secondary)
- Time Factors
- Translocation, Genetic
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