HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Time course of dehydrating effects of isosorbide on experimentally induced endolymphatic hydrops in guinea pigs.

Abstract
Osmotic diuretics are therapeutic agents used to reduce endolymphatic hydrops. However, glycerol-induced change in endolymph volume is followed by a rebound phenomenon. In this study, we investigated the rebound phenomenon occurring with isosorbide, an osmotic diuretic used as a therapeutic agent for Ménière's disease in Japan. Forty guinea pigs underwent surgical obliteration of the endolymphatic sac. Thirty received isosorbide orally 1 month after surgery. These animals were sacrificed 3, 6, or 12 h after isosorbide intake. The remaining 10 animals served as controls. Quantitative assessment of changes in the endolymphatic space was performed light-microscopically. Isosorbide reduced cochlear endolymph volume, with a peak reduction 6 h after intake. Thereafter, no prominent rebound phenomenon was noted. Clinically, since isosorbide is orally administered every 8 h, rebound phenomenon need not be considered in the treatment with isosorbide.
AuthorsAkinobu Kakigi, Setsuko Takeda, Taizo Takeda, Shoichi Sawada, Hiroshi Azuma, Kasumi Higashiyama, Kazuhiro Yamakawa, Shunji Takeuchi
JournalORL; journal for oto-rhino-laryngology and its related specialties (ORL J Otorhinolaryngol Relat Spec) Vol. 66 Issue 6 Pg. 291-6 ( 2004) ISSN: 0301-1569 [Print] Switzerland
PMID15668526 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright (c) 2004 S. Karger AG, Basel.
Chemical References
  • Diuretics, Osmotic
  • Glycerol
  • Isosorbide
Topics
  • Administration, Oral
  • Animals
  • Cochlear Duct (drug effects)
  • Disease Models, Animal
  • Diuretics, Osmotic (administration & dosage, chemistry, pharmacology, therapeutic use)
  • Endolymph (drug effects, metabolism)
  • Endolymphatic Hydrops (chemically induced, drug therapy)
  • Glycerol (chemistry, pharmacology)
  • Guinea Pigs
  • Isosorbide (administration & dosage, chemistry, pharmacology, therapeutic use)
  • Recurrence
  • Time Factors
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: