Abstract |
Osmotic diuretics are therapeutic agents used to reduce endolymphatic hydrops. However, glycerol-induced change in endolymph volume is followed by a rebound phenomenon. In this study, we investigated the rebound phenomenon occurring with isosorbide, an osmotic diuretic used as a therapeutic agent for Ménière's disease in Japan. Forty guinea pigs underwent surgical obliteration of the endolymphatic sac. Thirty received isosorbide orally 1 month after surgery. These animals were sacrificed 3, 6, or 12 h after isosorbide intake. The remaining 10 animals served as controls. Quantitative assessment of changes in the endolymphatic space was performed light-microscopically. Isosorbide reduced cochlear endolymph volume, with a peak reduction 6 h after intake. Thereafter, no prominent rebound phenomenon was noted. Clinically, since isosorbide is orally administered every 8 h, rebound phenomenon need not be considered in the treatment with isosorbide.
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Authors | Akinobu Kakigi, Setsuko Takeda, Taizo Takeda, Shoichi Sawada, Hiroshi Azuma, Kasumi Higashiyama, Kazuhiro Yamakawa, Shunji Takeuchi |
Journal | ORL; journal for oto-rhino-laryngology and its related specialties
(ORL J Otorhinolaryngol Relat Spec)
Vol. 66
Issue 6
Pg. 291-6
( 2004)
ISSN: 0301-1569 [Print] Switzerland |
PMID | 15668526
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright (c) 2004 S. Karger AG, Basel. |
Chemical References |
- Diuretics, Osmotic
- Glycerol
- Isosorbide
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Topics |
- Administration, Oral
- Animals
- Cochlear Duct
(drug effects)
- Disease Models, Animal
- Diuretics, Osmotic
(administration & dosage, chemistry, pharmacology, therapeutic use)
- Endolymph
(drug effects, metabolism)
- Endolymphatic Hydrops
(chemically induced, drug therapy)
- Glycerol
(chemistry, pharmacology)
- Guinea Pigs
- Isosorbide
(administration & dosage, chemistry, pharmacology, therapeutic use)
- Recurrence
- Time Factors
- Treatment Outcome
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